Since Endosulfan is a contact insecticide as opposed to a systemic one, it is not absorbed into crops or the food chain. It cannot bio-accumulate in the human body as it is continually degraded by metabolism to a lesser state of hazard.
- The Endosulfan evaluations conducted in 1998 by World Health Organisation (WHO), Food and Agriculture Organization (FAO) and Joint FAO/WHO Meeting on Pesticide Residues have recorded that no genotoxic activity was observed in an adequate battery of tests for mutagenecity and clastogenecity. This study categorically mentioned that no evidence was found to prove estrogenic activity involving Endosulfan.
- Endosulfan has been certified by WHO and FAO to not cause cancer, birth defects or any hormonal imbalance on contact.
- It is the opinion of the UN Environment Programme, International Labour Organisation, International Agency for Research on Cancer, the US Environmental Protection Agency (US-EPA) and California Department of Pesticide Registration, that Endosulfan has no carcinogenic potential.
- In 2007, US-EPA established that Endosulfan is not an anti-androgen, i.e. it does not affect sperm production, sperm count, motility, and the like.
- A peer review by Silva and Gammon (2009) declared that Endosulfan is not a developmental or reproductive toxicant or an endocrine disruptor.
- The WHO has classified Endosulfan as a Class II–moderately hazardous insecticide.
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